Frenchman Benoit Paire became the second seed to fall on day three of the tournament this afternoon, slumping to a 6-3 6-4 loss to Roberto Bautista Agut of Spain - a player ranked nearly 50 places below him.
Former world number 8 Marcos Baghdatis will also be on an early flight to Australia after being ousted by unheralded American Steve Johnson 7-5 6-7 (3) 6-4. Johnson was only included in the main draw as a "lucky loser" from qualifying after Frenchman Gael Monfils withdrew on the eve of the tournament.
With the match carried over from yesterday after rain forced the abandonment of last night's late session, Johnson will be back in action this evening with a second round match up against fourth seed Kevin Anderson of South Africa.
German Philipp Kohlschreiber advanced through to the third round with a straight forward 6-4 6-2 win over Argentina's Horacio Zeballos.
After a tricky first-round assignment against Spaniard Pablo Carreno Busta, Kohlschreiber was pleased with his clinical display today.
"Today was a new day. I played a great match and didn't make many mistakes. I served well, very clever with the wind. It's tricky in the wind. Overall I played a very clever and great game," said Kohlschreiber.
Kohlschreiber will meet John Isner in the third round after the big-serving American edged past Slovakia's Lukas Lacko this afternoon. Isner smashed a total of 21 aces - clocking 231km mid-way through the third set - as he overcame a slow start to defeat Lacko 7-6(1) 3-6 6-2.