For Statham, 24, taking on a player who has been inside the top 40 in his career is a big challenge but one he's looking forward to.
"It doesn't really matter who plays first - we're pretty easy with it. I've played him (Istomin) twice before now ... maybe it's third time lucky. I've learnt a lot and have a good strategy in place and have studied his matches," Statham said.
"The way I see it world rankings go out the window once you step on the court to play for your country. This is my 17th tie for New Zealand I've got a good record and I have pride playing for my country."
Statham is picked ahead of Artem Sitak who has the better ATP ranking, but less experience in Davis Cup.
Meanwhile, Uzbek No 1 Istomin struck a relaxed note about the contest.
"This is a different story playing for the country in best of five set matches. I will try to do my best and get the point for my country. It won't be easy, but I think we do it," he said.
In the doubles on Saturday, New Zealand have chosen Venus and Dan King-Turner, who had success at this year's Heineken Open and at a challenger event in Honolulu. Uzbekistan have chosen Istomin and Dustov, however combinations can be changed until an hour before play.
Teams
New Zealand (with ATP rankings):
Michael Venus (357)
Artem Sitak (424)
Rubin Statham (554)
Daniel King-Turner (484)
Marcel Vos (non-playing captain)
Uzbekistan:
Denis Istomin (58)
Farrukh Dustov (247)
Murad Inoyatov (524)
Sarvar Ikramov
Petr Lebed (non-playing captain)
Schedule for New Zealand vs Uzbekistan Davis Cup tie, beginning tomorrow in Tauranga:
Friday, February 10:
2.45pm - Opening ceremony
3pm - Rubin Statham (NZL) vs Denis Istomin (UZB)
Followed by
Michael Venus (NZL) vs Farrukh Dustov (UZB)
Saturday, February 11:
3pm - Venus/Dan King-Turner (NZL) v Istomin/Dus
Sunday, February 12
11am - Two reverse singles rubbers