Wimbledon champion Garbine Muguruza struggled with the heat and Hsieh Su-wei's game before losing 7-6 (1), 6-4 (4) as the upsets intensified at the Australian Open.
No3-ranked Muguruza follows Venus Williams and US Open champion Sloane Stephens out of the tournament in the first week, leaving only three major winners still in the women's draw — and two of them could meet in the third round.
Muguruza had five double-faults, including one to give No88-ranked Hsieh a match point, and made 43 unforced errors. She needed a medical time out in the first set, and accidently hit a ball into a line judge in frustration.
Hsieh, 32, is a former top-ranked doubles player who had only one previous win over a top 10 player and whose career-high singles ranking peaked at 23 in 2013.
On a day of 39 degree heat, Maria Sharapova was in a hurry to get off the Rod Laver Arena court, winning the first set in 23 minutes before advancing 6-1 7-6 (4) over 14th seed Anastasija Sevastova.