Andy Murray looks for revenge, Andreas Seppi chases another miracle, Maria Sharapova takes advantage of her great escape, and a New Zealander continues his doubles dream as Michael Burgess previews all the action from day seven.
Don't miss: Andy Murray vs Grigor Dimitrov
Potential for a spectacular battle here. Murray will be out for revenge against the Bulgarian, who dashed his hopes of defending his Wimbledon crown last year when he beat him in the quarter finals in London. The tenth seeded Dimitrov has got better with every outing here but it would still be an upset if he defeats the Scot; the last time Murray failed to reach the fourth round of a grand slam was in 2010 at the US Open.
Head to head: Murray leads 4-2
Could be a beauty: Nick Kyrgios vs Andreas Seppi
The Aussie wonder kid versus the Italian who beat Roger Federer, whose passing shot on match point will be talked about for as long as tennis is played in Melbourne. Seppi may find it hard to reach the same levels again - as often happens after a momentous victory - while Kyrgios is riding a wave of fanatical support, revelling in unexpected local success this year.
Head to head: Kyrgios leads 1-0
Worth a watch: Maria Sharapova vs Peng Shuai
Sharapova came back from the brink in the last round, the sort of omen that can end in the ultimate success. The world No 2 no longer has the fearsome power from the service line of days past, but remains a top competitor. Shuai has her own reasons to be confident, having reached the semi finals in her last major in New York. The Chinese player has beaten Sharapova before but it was back in 2009.
Head to head: Sharapova leads 4-1
Also worth a watch: Rafa Nadal vs Kevin Anderson
Nadal turned a major corner in his comfortable third round victory over Dudi Sela, and with every match the possibility of a title tilt looks more and more possible. Anderson will be a tough opponent for the Spanish world No 3, with his huge serves landing from an impossible angle. The tall South African has added new dimension to his game over the last 12 months, with much improved movement and footwork. He is also on a six match winning streak over left handers at Grand Slams - though Rafa ain't no ordinary lefty.
Head to head: Nadal leads 1-0
Best of the rest:
• Eugenie Bouchard vs Irina Camelia Begu. The Canadian Bouchard is a special player and looks on track for another successful run at a grand slam but shouldn't underestimate the Romanian world No 42.
Head to head: First meeting.