Defending champion Andy Murray reached the US Open quarter-finals for a third successive year with a 6-7 (5-7) 6-1 6-4 6-4 win over Uzbekistan's Denis Istomin today.
Third seed Murray overcame dropping a set for the second time in the tournament to set up a clash against Stanislas Wawrinka, the ninth-seeded Swiss, who put out Czech fifth seed Tomas Berdych.
World number one Novak Djokovic raced into the quarter-finals, where he will face explosive Russian Mikhail Youzhny, who staged two stunning comebacks Tuesday to beat 2001 champion Lleyton Hewitt.
Top seeded Djokovic, the 2011 champion, wrapped up a place in his 18th successive Grand Slam quarter-final when he crushed Spanish world number 43 Marcel Granollers, 6-3 6-0 6-0 in just 79 minutes.
Russian 21st seed Youzhny, a semi-finalist in 2006 and 2010, carved out a four-hour, 6-3 3-6 6-7 (3-7) 6-4 7-5 win over Hewitt after trailing 4-1 in the fourth set and 5-2 in the fifth.