The Blues have suffered a series of potentially crippling blows to their Super Rugby campaign with three players sustaining serious injuries in the season-opener against the Chiefs at the weekend.
In a statement, the Blues confirmed All Black wing Rieko Ioane - who scored two tries at Eden Park - will be out of action for "several weeks" after fracturing his hand.
Hooker Ray Niuia has suffered a season-ending knee injury while prop Alex Hodgman has a calf tear.
The Blues confirmed that veteran hooker James Parsons and first-five Otere Black are both expected to return from injuries as early as this week.
The Blues went down 37-29 after a second-half fightback from Warren Gatland's team on Friday evening.