The Hurricanes leave for Brisbane today looking for improvements after a subdued performance against the Blues on Saturday, and Smith's leadership and defensive nous against the likes of dangermen Quade Cooper and Digby Ioane could be crucial.
The Reds lost their opener to the Brumbies in Canberra but responded with a victory over their closest rivals the Waratahs at Suncorp Stadium - although, after leading 17-3 at one point they needed a late Ben Tapuai try to break a 17-all deadlock to win.
Hurricanes coach Mark Hammett has made only one change to the starting XV, with Jeffery Toomaga-Allen coming in at tighthead prop for Ben May. An improved performance up front will be a particular focus for Hammett.
First-five Beauden Barrett and halfback TJ Perenara, two bright young things from last season, will also be looking to make greater impacts.
On the reserves bench, hard-hitting hooker Motu Matu'u is in line to make his first appearance for his team this year. Lock James Broadhurst will wear the No 18 jersey ahead of Mark Reddish, who has a hamstring injury.
Meanwhile, hookers Hika Elliot and Mahonri Schwalger are coming into the frame for the Chiefs' Saturday night match against the Cheetahs at Waikato Stadium in Hamilton.
Elliot missed his team's opening victory over the Highlanders in Dunedin because of a calf injury suffered late in the week, with Schwalger sidelined following knee surgery.
In the absence of the pair, Rhys Marshall, a 20-year-old who has yet to play a senior provincial match, made a fine fist of his Super 15 debut.
The Cheetahs travel to Hamilton after losing their opening match to the Sharks in Bloemfontein.
Hurricanes v Reds
Suncorp Stadium, Brisbane
Friday, 11.20pm
Andre Taylor, Alapati Leiua, Conrad Smith (c), Tim Bateman, Julian Savea, Beauden Barrett, TJ Perenara, Brad Shields, Karl Lowe, Victor Vito, Jason Eaton, Jeremy Thrush, Jeffery Toomaga-Allen, Dane Coles, Ben Franks. Reserves: Motu Motu'u, Reggie Goodes, James Broadhurst, Faifili Levave, Chris Smylie, James Marshall, Reynold Lee-Lo.