Wallabies playmaker Quade Cooper will be sidelined for up to 12 weeks after fracturing his collarbone at Queensland Reds training on Thursday.
The 26-year-old missed four months last year due to an AC joint injury and the fracture occurred around the previous operation site.
He will undergo surgery on Tuesday with a Reds media statement on Friday night saying he would be out for "10-12 weeks".
Cooper said the setback was hard to take.
"I'm gutted to be missing the start of the season," he said.