Blues centre George Moala has re-aggravated his knee injury in Cape Town and is on his way home to Auckland.
Moala, who was a late withdrawal from the Blues' team before their round one 23-18 loss to the Chiefs at North Harbour in the weekend, has been replaced by Melani Nanai.
The other big change for the Blues is the fact Charles Piutau will start at fullback against the Stormers at Newlands on Sunday morning after starting on the right wing last weekend.
Prop Charlie Faumuina has been bracketed with Angus Ta'avao and lock Patrick Tuipulotu bracketed with Hayden Triggs and Josh Bekhui. Brendon O'Connor, Luke Braid and Akira Ioane have been bracketed for the No7 jersey and Tevita Li and Lolagi Visinia for the left wing position.
Coach John Kirwan said Moala aggravated his medial ligament in an early training session, adding his reasoning around bracketing his two locks with All Black Tuipulotu was tactical.