South Africa will be without lock Victor Matfield and second-five Jean de Villiers for their next encounter with Fiji in Wellington on Saturday, while Bakkies Botha remains unavailable after the opening days of the Rugby World Cup.
Matfield left the field at half-time during the Springboks' 17-16 win over Wales last night after he felt his hamstring tighten, while de Villiers suffered a rib cartilage injury.
Botha has been battling an Achilles tendon injury, which forced him out of the Welsh clash, and the problem isn't responding to treatment.
Springboks' team doctor Craig Roberts said today: "The two concerns from the [Wales] game were obviously Jean de Villiers who has picked up a ... grade-one rib cartilage sprain. We anticipate he'll probably be out for about 10 days with that," Roberts said.
"It was more of a precaution. We didn't want to make it a lot worse on the field so we made the decision to bring him off and the other one in a similar boat was Victor Matfield, who started feeling his hamstring tighten up. He'll also need a couple of days - 10 days or so.