It is also the most experienced South African team of all time, boasting a total of 815 caps, which surpasses the previous total of 810 - a record set against Australia in Durban last month.
Sunday's game kicks off at 8.30pm and Wales will name their squad this afternoon.
South Africa: 15 Frans Steyn, 14 JP Pietersen, 13 Jaque Fourie, 12 Jean de Villiers, 11 Bryan Habana, 10 Morne Steyn, 9 Fourie de Preez; 8 Pierre Spies, 7 Schalk Burger, 6 Heinrich Brossouw, 5 Victor Matfield, 4 Danie Rossouw, 3 Jannie de Plessis, 2 John Smit (captain), 1 Tendai Mtawarira; Substitutes: 16 Bismarck du Plessis, 17 Gurthro Steenkamp, 18 CJ van der Linde, 19 Johann Muller, 20 Willem Alberts, 21 Francois Hougaard, 22 Butch James.