Queensland Reds back-rower Scott Higginbotham is set to make his Wallabies starting debut against the Springboks in Durban on Saturday.
After impressing off the bench in Australia's opening two Tri Nations Tests, Higginbotham is expected to replace Ben McCalman at No.8 when coach Robbie Deans names his side later on Thursday.
In the only other likely change to the run-on team which lost 30-14 to the All Blacks in Auckland last Saturday, veteran lock Nathan Sharpe may replace young Reds second-rower Rob Simmons, who is experiencing some shoulder discomfort.
Sharpe, omitted from the match-day 22 against New Zealand, trained with the Australian starting team on Wednesday and is hoping to get the call-up for his 96th Test.
Deans is backing young winger James O'Connor to return to form with the boot at Kings Park after being retained as first-choice goalkicker despite missing all three of his attempts at Eden Park.