Ireland lost a second Lions centre yesterday from the Six Nations, while Wales felt like they had gained one. Whatever influence the late withdrawal of Keith Earls has on tonight's Dublin dust-up, nobody will derive any pleasure from his absence.
While Jamie Roberts was declared fit for Wales, it was announced that Earls will remain in his hometown of Limerick with his partner, Edel McGee, and their first child. Ella-Maye was born last week, only for complications to arise with her health. She has been re-admitted to hospital, although the nature of her illness remains unclear.
The news will inevitably lend some perspective to a confrontation which has been billed with the obligatory "revenge" tag. If Ireland's defeat by Wales in the 2011 World Cup quarter-final hurt, their Six Nations loss last year in Cardiff was wrapped in bitterness.
Matthew Rees took a quick throw-in with the wrong ball, Mike Phillips scored and the try cost Ireland the Triple Crown. Cue accusation and enmity.
It has always been thus between these two, whose familiarity in Celtic league competition only adds to any contempt. There is always a talking point, a controversy to overshadow the contest. Except in Wellington in the first week of October. Then, there were no excuses as Wales outplayed and out-thought their rivals, and a 22-10 scoreline was the very least their dominance deserved. Yesterday, as he finally named his Wales team, coach Warren Gatland provided his usual frank analysis of Ireland's inadequacy that day.