Springboks coach Peter de Villiers has recalled World Cup winners Juan Smith and JP Pietersen with Smith teaming up with Pierre Spies and Schalk Burger in the loose forward trio.
Gio Aplon moves from the wing to fullback while there's a new midfield pairing Jean de Villiers and Juan de Jongh.
Francois Hougaard makes his first start at halfback.
Up front, Jannie du Plessis returns at tighthead prop and rookie lock Flip van der Merwe starts in place of Danie Rossouw.
SOUTH AFRICA
15-Gio Aplon, 14-JP Pietersen, 13-Juan de Jongh, 12-Jean de Villiers, 11-Bryan Habana, 10-Morne Steyn, 9-Francois Hougaard, 8-Pierre Spies, 7-Juan Smith, 6-Schalk Burger, 5-Victor Matfield, 4-Flip van der Merwe, 3-Jannie du Plessis, 2-John Smit, 1-Gurthro Steenkamp.
RESERVES
16-Chiliboy Ralepelle, 17-C.J. van der Linde, 18-Danie Rossouw, 19-Francois Louw, 20-Enrico Januarie, 21-Butch James, 22-Wynand Olivier.
- NEWSTALK ZB
Rugby: Sweeping changes for Boks
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