France's hopes for the Six Nations were dealt a huge blow towards the end of the first half here, when Clermont's centre, Wesley Fofana, a key member of Les Bleus' midfield, ruptured his Achilles tendon. He will now miss the entire championship.
In a statement on their website, Clermont said the 29-year-old would need an operation on his left leg.
In the game itself, Exeter's hopes of a Champions Cup quarter-final were ended by a ruthless first-half display from Clermont Auvergne, who bagged five tries to lead 34-0 at the break.
The Chiefs had to play the latter stages of the half with only 13 men after losing Olly Woodburn and Ollie Devoto to controversial yellow cards in the space of only two minutes.
However, they showed guts and determination to grab four tries after the interval to claim a positive or two to take back to Devon.