Substitute hooker Kianu Kereru-Symes is set to play his blazer game against Poverty Bay while Mark Braidwood will make his first appearance for the Magpies since 2018 at prop.
The veteran loosehead is back in the squad to help cover the injured Namatahi Waa, who along with Jacob Devery and Gareth Evans will miss the entire season.
Lolani Faleiva will probably replace Braidwood off the bench against Poverty Bay having graduated from 2021 apprentice to a full-time contract this year.
Lock/loose forward Tiaki Fabish has been promoted as well, although even with the departure of Geoff Cridge to French club Bayonne, minutes in the second row will be hard to come by.
Hawke's Bay have recruited Tongan international and Moana Pasifika forward Sione Tu'ipulotu, bolstering a group that already included Parsons, Isaia Walker-Leawere, Bryn Evans, and another youngster in Frank Lochore.
The bulk of the 2021 Magpies have returned with only Ash Dixon, Tiaan Falcon (both Japan), Brendon O'Connor (New York) and Cridge departing.
In addition to Tu'ipulotu, the Magpies announced the signing of Scottish international midfielder Nick Grigg from Osaka Red Hurricanes in Japan.
The 29-year-old is one of five new faces for 2022 along with Tu'ipulotu, utility back Chase Tiatia, hooker Tyrone Thompson and openside flanker Sam Smith.
The squad features two current All Blacks (Brodie Retallick and Folau Fakatava), four current internationals each from Samoa (Ereatara Enari, Danny Toala, Lolagi Visinia, Neria Foma'i) and Tonga (Joe 'Apikotoa, Sione Tuipulotu, Solomone Funaki, Anzelo Tuitavuki), and three Māori All Blacks (Tyrone Thompson, Isaia Walker-Leawere, Brad Weber).
Of the 44 fully contracted players, 27 played in Super Rugby Pacific this year.
Magpies head coach Josh Syms said he is excited to be able to call on so many players with high-level experience, especially given the departures of Dixon and O'Connor.
"We are looking forward to seeing new leaders develop and all players adding valuably to our team," he said.
New Magpies assistant coach Brock James echoed Syms' excitement and added that he is looking forward to the challenge of the NPC.
''The work done over the last four years by this group of players and the staff has put Hawkes Bay rugby in a very strong position."
Hawke's Bay Magpies to play Poverty Bay at McLean Park on Saturday, kickoff 3.05pm
1. Mark Braidwood
2. Gene Syminton
3. Joel Hintz
4. Isaia Walker-Leawere
5. Tom Parsons (c)
6. Josh Gimblett
7. Sam Smith
8. Tupou Ma'afu Afungia (debut)
9. Brad Weber
10. Caleb Makene
11. Anzelo Tuitavuki
12. Danny Toala
13. Neria Foma'i
14. Ollie Sapsford
15. Harry Godfrey
16. Kianu Kereru-Symes (blazer game)
17. Lolani Faleiva
18. Joe 'Apikotoa
19. Bryn Evans
20. Tiaki Fabish
21. Ereatara Enari
22. Stacey Ili
23. Kienan Higgins
2022 Hawke's Bay Magpies Bunnings NPC squad
Props
Jason Long (Hastings), Pouri Rakete-Stones (Napier Pirate, Hurricanes), Joe 'Apikotoa (Taradale, Moana Pasifika), Namatahi Waa (Taradale, Austin Gilgronis, injured), Joel Hintz (Central), Lolani Faleiva (Taradale, Toronto Arrows), Mark Braidwood (Napier Tech), Lewis Bush (Napier Tech, apprentice)
Hookers
Kianu Kereru-Symes (Tamatea, Hurricanes), Jacob Devery (Hastings, Hurricanes, injured), Tyrone Thompson (Napier Tech, Chiefs), Gene Syminton (Taradale)
Locks
Tom Parsons (Central, Hurricanes), Isaia Walker-Leawere (Clive, Hurricanes), Bryn Evans (Havelock North, Highlanders), Brodie Retallick (Central, Chiefs, All Blacks), Frank Lochore (Central), Sione Tu'ipulotu (MAC, Moana Pasifika), Tiaki Fabish (NOBM)
Loose Forwards
Josh Kaifa (Clive, Moana Pasifika), Sam Smith (Havelock North), Will Tremain (NOBM), Gareth Evans (Havelock North, Highlanders, injured), Marino Mikaele-Tu'u (Hastings, Highlanders), Solomone Funaki (MAC, Moana Pasifika), Devan Flanders (Havelock North, Hurricanes), Josh Gimblett (Eskview), Tupou Ma'afu Afungia (MAC, apprentice)
Halfbacks
Brad Weber (NOBM, Chiefs, All Blacks), Folau Fakatava (Hastings, Highlanders, All Blacks), Ereatara Enari (Tamatea, Moana Pasifika), Connor McLeod (Hastings)
First five eighths
Lincoln McClutchie (Tamatea, Moana Pasifika), Caleb Makene (Taradale, Utah Warriors), Harry Godfrey (Central)
Midfield
Danny Toala (Hastings, Moana Pasifika), Nick Grigg (Central, Osaka Red Hurricanes), Neria Foma'i (Hastings, Moana Pasifika), Stacey Ili (NOBM, Melbourne Rebels), Chase Tiatia (Napier Tech, Chiefs), Dennon Robinson-Bartlett (Tamatea, Toronto Arrows), Zaccheaus Simpson (Central, apprentice)
Outside Backs
Jonah Lowe (Clive, Chiefs), Lolagi Visinia (Clive, Moana Pasifika), Anzelo Tuitavuki (Clive, Moana Pasifika), Ollie Sapsford (Taradale, Brumbies), Kienan Higgins (Taradale), Paoaraian Manuel-Harman (NOBM, apprentice)