Prop Paul James has undergone eye surgery and with a recommended layoff of being six to 10 weeks, he is another who will be sidelined along with wing Alex Cuthbert who has had a knee operation.
Talented fullback Leigh Halfpenny has struggled with a range of injuries in the last year, missed the World Cup and is battling a setback from prolonged knee trouble.
He was expected to return for his Toulon club this month however French media report he will not feature in any matches, a prognosis which would make it awkward to then pick him for the trip to New Zealand.