Prop Paddy Ryan and uncapped winger Tom English have been added to the Wallabies Rugby Championship squad, with hamstring injuries set to rule out Laurie Weeks and Joe Tomane for the first two matches against New Zealand.
Both injuries are considered relatively minor, with Weeks and Tomane each expected to be out for two to three weeks.
However, that would be long enough to rule them out of the Rugby Championship and Bledisloe Cup games against New Zealand in Sydney next Saturday and in Auckland the following weekend.
"It's disappointing to lose Laurie and Joe at this point," Wallabies coach Ewen McKenzie said.
"But as has been consistent with our stance on injuries over the past year, we're going to continue to take a pragmatic approach and give guys with issues the chance to focus solely on their rehab before rejoining the squad.