England Billy Vunipola will miss the All Blacks test next month after breaking his arm for the third time in 12 months.
Vunipola faces another 12-week lay-off after Saracens confirmed that the No 8 fractured his left arm against Glasgow Warriors on Sunday.
The injury, which forced him from the field during the second half of a 13-3 win for the Premiership champions at Scotstoun, will require surgery and is sure to rule him out of England's autumn fixtures against South Africa, Japan, New Zealand and Australia.
To compound matters for Saracens coach Mark McCall, and possibly Eddie Jones, Saracens also revealed that his brother Mako picked up a calf strain. According to Saracens his "progress will be monitored".
And in a third injury blow to Sarries, following a bad-tempered Heineken Champions Cup encounter, Nick Isiekwe suffered an ankle sprain.