Moody has played only two Super Rugby matches this season due to a thumb injury and a two-week suspension. His Crusaders mate Franks has played four due to his recovery from off-season Achilles tendon surgery and his own two-week suspension.
Whitelock hasn't played for four weeks due to a concussion, while vice-captain Cane hasn't played for the Chiefs since April 21 due to an abdominal strain.
"It has been continually 'I should be right this week' but I haven't been," Cane said. "The timing's right. I might be short of a gallop but I'll just go out there and empty the tank."
Of the five, blindside flanker Squire is perhaps the best placed in terms of recent game time; he's played the last two weeks for the Highlanders after recovering from a broken thumb but only five this season.
There is another question mark over the pack in terms of how reserve Vaea Fifita, who has been seen as a loose forward by the All Black selectors until now, goes at lock.
The plan is to replace Whitelock with Fifita in the second half but it is one that will obviously change should the increasingly important Scott Barrett receive an injury.
Should the replacements go to plan, right wing Ben Smith's leadership suddenly becomes extremely important, as he will be the captain once Whitelock and Cane leave the field.
"We're going to have to be smart about when we use our bench," Hansen told the Weekend Herald.
"You're right, there are a lot of guys that haven't played a lot of footy but they've been able to train and get the running in. Sam and Sam have probably been the two exceptions.
"Both Joe and Owie have been doing a lot of wrestling and rugby-type mauling and running, so I'm reasonably confident they'll be okay. Liam has had two games now on the trot and is a naturally fit guy anyway and we have a ready-made replacement in Ardie for Sam [Cane].
"So, confident that what we've got will do the job but we've just got to be aware of how we're travelling and make sure we make the subs at the right time."
The Fifita experiment is an interesting one, too.
The 25-year-old has played all five of his tests as a loose forward and while he has played lock for the Hurricanes, until now the All Blacks have never considered him ready to play there at test level.
"We wanted to have more cover for the loose forwards really than lock because we know that Scooter [Scott Barrett] will go deep into the game and we know that [Vaea] can play lock," Hansen said.
"We haven't wanted to use him as a lock at this level before but we've probably got to the time now where we've got to play around and see what we've got, particularly when Scooter's not available and Brodie and Sam are the two starting locks."