Ben Tapuai and Adam Ashley-Cooper will become the Wallabies' eighth centre pairing used in 13 Tests this year when they take on England at Twickenham.
The injury-ravaged Wallabies have used 41 players in 12 Tests and lost regular inside centre Pat McCabe to a neck strain during the week, forcing coach Robbie Deans to reshuffle his backline for Saturday's (Sunday AEDT) clash.
Digby Ioane returns on the wing with Ashley-Cooper pushing to his preferred spot of No.13, leaving Tapuai to move in from outside centre to No.12, a position he plays regularly with Queensland.
Tapuai, 23, will be lining up in just his fifth Test and his first at inside centre for Australia and is marking South African-born No.12 Brad Barritt.
While Ashley-Cooper faces the daunting task of stopping Samoan-born, 110kg giant, Manusamoa Tuilagi.