But with the irregular rhythms now controlled through medication, Fruean has a chance to show he does indeed have a future in the sport.
"It's opportune timing for him," said assistant coach Andrew Strawbridge. "He worked really hard to get himself back in the frame and there's a bigger picture for him.
"Not just winning selection for this game but proving to himself and everybody else that he's got a long-term future in the game. So it's a really good opportunity for him and we're very excited that he's back."
While Fruean's size and physicality will boost a Chiefs backline that has struggled for consistency this season, his inclusion has also provided a mental lift for his teammates.
"It's golden when you have someone who's working that hard to create an opportunity for themselves," Strawbridge said. "He's not the only one - there are a number of guys who have been working really hard to try and create an opportunity for themselves around selection."
Among them is Augustine Pulu, who has also battled back to full fitness after a spell on the sidelines. The halfback has recovered from knee surgery - aided by the timing of the international break - to again take up his duel with Tawera Kerr-Barlow for the No9 jersey.
With Kerr-Barlow having been occupied on All Black duty, Pulu has earned the nod to clash with Aaron Smith and enforce some of the tweaks the Chiefs made to their game over the June window.
"We had [Pulu] to work with while Tawera's been away and he understands some of these things that we're trying to change in our game," Strawbridge said.
The remainder of the Chiefs' All Black contingent have slotted straight into the starting side, with Aaron Cruden's selection at first-five seeing Gareth Anscombe shift to fullback, while Liam Messam and Brodie Retallick will bolster the champs' pack.
Chiefs: Gareth Anscombe, Dwayne Sweeney, Robbie Fruean, Bundee Aki, Tom Marshall, Aaron Cruden (c), Augustine Pulu, Liam Squire, Tanerau Latimer, Liam Messam, Brodie Retallick, Michael Fitzgerald, Ben Tameifuna, Mahonri Schwalger, Pauliasi Manu. Reserves: Nathan Harris, Jamie Mackintosh, Josh Hohneck, Matt Symons, Tevita Koloamatangi, Tawera Kerr-Barlow, Tim Nanai-Williams, James Lowe.