It looms as a colossal positional battle between two of the most exciting players in world rugby.
While the Waratahs game-breaker stands one centimetre taller and gives away seven kilos in weight to the 31-Test Welsh flyer, it's Folau's inexperience in the Test arena which gives rise to one of the biggest question marks over the Australian line-up.
But coach Deans is more than happy to gamble on his talent, adaptability and big-match temperament to meet the high intensity and pressure of an encounter that Will Genia expects will be as tough, or tougher, than meeting the All Blacks.
Lions assistant coach Rob Howley on Wednesday night painted a graphic picture of what awaits the former Bronco, Melbourne Storm star and GWS Giant in the series-opener.
Howley rated North, 21, among the top few players he'd been associated with in 10 years of coaching, lauding his "physicality, power, speed'' and marvelling his game was only getting better.
"When you're able to bring in him in the 10 channel or out in the 13 channel or staying wide through a passing game he's been pretty instrumental,'' the Lions backs mentor said.
"His work-rate off the wing is phenomenal. It's something we want our wingers to do ... to have involvements because you want your best players on the ball as often as possible.''
Deans will want the same from Folau, as he must immediately stand up and thrive in the Test arena against his world-class rival.
While one Welsh giant has been cleared, the Lions must overcome the loss of another with centre Jamie Roberts struggling with his own hamstring injury.
Wallabies team:
15. Berrick Barnes, 14. Israel Folau, 13. Adam Ashley-Cooper, 12. Christian Leali'ifano, 11. Digby Ioane, 10. James O'Connor, 9. Will Genia, 8. Wycliff Palu, 7. Michael Hooper, 6. Ben Mowen, 5. James Horwill (captain), 4. Kane Douglas, 3. Ben Alexander, 2. Stephen Moore, 1. Benn Robinson. Reserves: 16. Saia Fainga'a, 17. James Slipper, 18. Sekope Kepu, 19. Rob Simmons, 20. Liam Gill, 21. Nick Phipps, 22. Pat McCabe, 23. Kurtley Beale.
- AAP