South Africa were forced to select 35-year-old veteran Frans Steyn at first-five for the decisive final game of the Rugby Championship against Argentina.
The Springboks were already missing their top two No 10s, Handre Pollard and Elton Jantjies, before stand-in Damian Willemse sustained a concussion in the 36-20 win over the Pumas in Argentina last Saturday.
That has forced coach Jacques Nienaber to give Steyn, an impact player off the bench for the last three years, a rare start on Sunday.
South Africa made one more change to their starting 15 by bringing flanker Pieter-Steph du Toit back for Franco Mostert.
Nienaber also reverted to a six-two split of forwards and backs on the bench for the game in Durban, meaning reserve halfback Faf de Klerk must also cover at first five-eighth if needed. Wing Kurt-Lee Arendse is the other back on the bench after serving a four-week suspension for a dangerous tackle on New Zealand's Beauden Barrett in the opening round of the tournament.