Wallabies coach Michael Cheika has hinted that Tevita Kuridrani will be retained the outside centre role but there is a big question mark over who will fill the inside centre sport with World Cup choice Matt Giteau absent and Kurtley Beale injured.
That leaves Leali'ifano, Israel Folau, Karmichael Hunt, Reece Hodge and Samu Kerevi as possibilities.
Kerevi and Kuridrani are tipped to team up in a big-bodied centre combination that would blunt an anticipated England debut by former NRL star Ben Te'o.
Te'o is considered a strong chance of playing in the centres for the tourists, capping a remarkable rise in rugby union since quitting rugby league in 2014.
Wallabies defence coach Nathan Grey believed Te'o's inexperience on the international stage could be tested.
"He's a great talent. He provides a really good strong ball-carrying centre," Grey said.
"He's certainly on the sharper end of the queue in terms of being across what his
strengths and weaknesses are."
Asked what his weakness was, Grey said: "His time in the game.
"He's been playing for a number of years now.
"But obviously taking that step up and playing international level is a big step.
"Everything gets tested at a higher level - you've got less time, less space.
"Your skills and execution under pressure is the hardest thing to replicate."
Grey baulked when asked if the Wallabies would target Te'o.
"You are soothsaying a little bit there," he said.
"Guys can step up to that level pretty quickly."
- AAP
