But while Pene and Sironen make quick returns, first-choice centre Rocco Berry is also back in the mix after sitting out last week with a virus and fellow young centre Viliami Vailea is on the extended bench having recovered from the knee injury which sidelined him after the first-round defeat by St George Illawarra.
Sironen, who was on the bench in the first three rounds, comes into the second row with Josh Curran reverting to loose forward.
For the first time this season, Brown has been able to select the same spine in successive weeks, with Wayde Egan at hooker, Shaun Johnson and Chanel Harris-Tavita in the halves, and Reece Walsh at fullback.
Until now Egan had been the only constant in the opening month.
In round one, Johnson was with Kodi Nikorima in the halves with Harris-Tavita at fullback while a week later Walsh came in at fullback with Harris-Tavita going to the halves alongside new signing Ash Taylor.
There was another shuffle ahead of round three when Taylor (hip) was ruled out and Nikorima was back in the halves.
It meant Brown was unable to field his preferred spine until last week when Johnson came back from injury.
Last week Matt Lodge, Jesse Arthars, Nikorima and Walsh all lined up against their former club Brisbane; this week the Warriors will face three former players in centre Peta Hiku, halfback Chad Townsend and prop Jamayne Taunoa-Brown.
Warriors team
1 Reece Walsh
2 Edward Kosi
3 Jesse Arthars
4 Adam Pompey
5 Marcelo Montoya
6 Chanel Harris-Tavita
7 Shaun Johnson
8 Bunty Afoa
9 Wayde Egan (c)
10 Matt Lodge
11 Euan Aitken
12 Bayley Sironen
13 Josh Curran
Interchange:
14 Kodi Nikorima
15 Eliesa Katoa
16 Aaron Pene
17 Jack Murchie
Extended bench:
18 Taniela Otukolo
20 Addin Fonua-Blake
21 Rocco Berry
22 Pride Petterson-Robati
23 Junior Ratuva
24 Viliami Vailea
25 Otukinekina Kepu
• The Warriors face the Cowboys at Moreton Daily Stadium, Brisbane on Friday at 8pm.