North Queensland were dealt a blow on Friday, with coach Neil Henry confirming star centre Brent Tate had not recovered from a rib injury before the start of the NRL season.
The news is slightly better for key Cowboys' recruit Robert Lui (knee), who remains an outside chance of taking his place on the Cowboys bench to face Gold Coast in their season-opener on Saturday night despite not being named in the team on Tuesday.
Tate, who suffered the rib cartilage injury in a trial loss to Gold Coast a fortnight ago, has been unable to take part in contact training sessions, with Henry all but ruling him out of the clash at Dairy Farmers Stadium.
Tate, who was named alongside Kane Linnett in the centres by Henry, will be given up until an hour before the game to prove his fitness - and whether he'd be ready to face the challenge of reining in powerful Titan Jamal Idris.
"It's one of those things that if you can cope with (it's ok but) it's not a position on the body you'd want to try to put a needle into, around the lungs as well," Henry told reporters on Friday.