The stage was set for an emotional night for the hosts after the 18,265-strong crowd was treated to a pre-match tribute on the big screen to nine departing Titans - including four foundation players.
But the retiring Campbell was the name on everyone's lips as he led out the Titans for the last time - that was until Hayne cut loose.
Parramatta led 22-0 at halftime after Hayne set up three tries - including a double to winger Ryan Morgan - but the highlight was his stunning 11th minute effort.
Campbell looked set to score in the lead-up before throwing a desperate pass on the try-line, ricocheting off a player and lobbing in Hayne's hands in the in-goal area.
From a standing start, Hayne cut through the Titans and set sail down the left sideline to score despite a looming David Mead.
Hayne picked up where he left off in the second half, setting up two Ben Smith tries in three minutes with kicks to blow the score out to 32-0 by the 48th minute.
The Titans did not get on the board until the 69th minute when Luke O'Dwyer scored - converted by Campbell.
Mead then scored on the stroke of fulltime with departing Titan Anthony Laffranchi converting - as they crashed to a fourth straight loss.
The win finally snapped a seven game losing streak by the unlucky Eels, who featured in the NRL grand final just two years ago.
Their lean run included three one-point losses in golden-point extra-time.
PARRAMATTA 32 (R Morgan 2 B Smith 2 J Hayne K Sio tries L Burt 4 goals) bt GOLD COAST 12 (D Mead L O'Dwyer tries P Campbell A Laffranchi goals) at Skilled Park. Referee: Chris James, Brett Suttor. Crowd: 18,265.