Brisbane have suffered a big blow before Friday's night's NRL blockbuster clash with South Sydney, losing Test centre Justin Hodges and forward Josh McGuire to injury.
Neither player took part in the Broncos' final training session at Red Hill on Thursday morning.
The losses are a serious blow to sixth-placed Brisbane's chances of beating second-placed South Sydney who come to Brisbane at full strength and at the top of their game with a 5-1 record.
Hodges, with a groin injury, and McGuire who returned from a calf injury against West Tigers last weekend were ruled out after failing late medical tests.
Youngster Jordan Kahu, who has played a handful of NRL games, comes into the centres for Hodges while Jarrod Wallace replaces McGuire on the bench.