Broncos 26 Knights 6
Brisbane weakened Newcastle's tenuous grip on a top-eight berth, but their win may have come at heavy price.
Star centre Justin Hodges is in danger of missing the remainder of the NRL season after limping to the bench six minutes into the second half with his third hamstring injury of the season.
The Knights, now level with ninth-placed South Sydney with two rounds remaining, also lost players.
Junior Sau went off early with an ankle injury, and Matt Hilder was taken by ambulance to hospital with a nasty gash after a head clash with teammate Joel Edwards.