Jarryd Hayne has been ruled out of Australia's upcoming Four Nations campaign with the Parramatta star to undergo intensive treatment on a groin injury.
Hayne was one of four players - along with departing Penrith skipper Petero Civoniceva, Gold Coast's Ashley Harrison and Titans-bound centre Jamal Idris - to be withdrawn from the Kangaroos train-on squad on Monday.
Eels five-eighth/fullback Hayne was expected to be included in the final squad, where his utility value would no doubt have come in handy for Test coach Tim Sheens.
He is not expected to undergo surgery, with Eels officials hopeful of having him fully fit ahead of pre-season training.
Civoniceva tore a pectoral muscle in his Panthers finale while Idris - who played in Australia's mid-year Test win over New Zealand - was unavailable due to wrist surgery ahead of his move from Canterbury to the Gold Coast.