Glenn Stewart will miss next Wednesday's State of Origin decider in Brisbane after failing a fitness test on his injured knee.
The Manly back-rower partially tore the medial ligament during the Sea Eagles' clash with Melbourne two weeks ago, but was named in an extended squad by Blues coach Ricky Stuart last Sunday.
Stewart has not trained with the rest of the squad since joining camp last Monday and has undergone intense physiotherapy all week.
However, after undergoing running drills with the Blues' medical team yesterday at Kogarah Oval, the 28-year-old was ruled out of the Suncorp Stadium showdown and will be replaced by St George Illawarra's Beau Scott.
Scott played in two of last year's three games and will line up on the right-hand side, with Tony Williams filling the bench spot after Trent Merrin was sent back to the Dragons on Thursday.