"The Manly Warringah Sea Eagles family is extremely saddened to learn of the passing of player Keith Titmuss today," the club confirmed in a statement.
"Keith was a very promising young forward who had come through the Sea Eagles junior representative teams as a teenager."
Manly coach Des Hasler said: "We are all devastated by this news.
"Keith was a very popular character amongst the playing group. He will be sorely missed but never forgotten by the Sea Eagles."
Channel 9 sports reporter Danny Weidler tweeted: "He was a genuine rising star of the game. Experienced what has been described to me by club officials as a 'body cramp' whilst stretching after session. Doctor treated him at training and taken by ambulance to hospital. Thoughts are with his family."
Sea Eagles chief executive Stephen Humphreys said: "Our club sends its deepest condolences to Keith's family and friends and will provide them with all of the support they need during this difficult period.
"We are working with the NRL's Wellbeing team to offer support and counselling to our playing group and staff."
NRL chief executive Andrew Abdo called it a tragic day for rugby league.
"The game has lost a promising young player with the world at his feet," Abdo said in a statement.
"Keith had made it into Manly's top 30 for the 2021 season after coming through the club's junior ranks.
"We will make sure Keith's family, the club and our players receive every support they need from the game.
"We are one family and today we have lost a member of that family. On behalf of the Commission and the game I send my deepest condolences to Keith's family.