The Springboks, though, were beginning to threaten regularly and a scintillating run by fullback Willie Le Roux tore through the heart of the Irish defence but again the hosts escaped as they were awarded a penalty.
In an enthralling encounter Ireland also produced some fine running rugby of their own with fullback Rob Kearney breaking through the visitors defence and pressured the 'Boks into conceding a penalty.
Sexton made no mistake to make it 6-0 with a quarter of an hour remaining of the first-half.
The Springboks deciding that they had the Irish scrum under the cosh in the set pieces twice decided to kick for the corner than at goal but the hosts held firm and an infraction by Bismarck du Plessis allowed Sexton to clear.
Pollard finally gave the 'Boks something to show for their pressure during the opening period with a penalty in front of the posts two minutes from the break.
However, it was the Irish who struck first in the second-half as Devan Toner won a lineout a few yards out from the line and Ruddock was on hand to go over on the blindside - Sexton converted brilliantly from wide out on the left for 13-3.
Springboks coach Heyneke Meyer rang the changes bringing on experienced campaigners flanker Schalk Burger, winger JP Pietersen as well as hooker Adriaan Strauss - whose cousin Richardt Strauss was on the Irish bench - in the first 10 minutes of the second-half desperately trying to get some momentum going.
Finally, though, South Africa's relentless pressure told as they won a lineout having opted again to go for the corner, after being awarded a penalty, veteran Victor Matfield won the lineout and Marcell Coetzee was on hand to touch down - Pollard converted for 13-10.
Sexton, who had gone down at one point and seemed to be feeling his calf, put over a penalty to give Ireland a 16-10 lead as the game entered the final 20 minutes.
The hosts were given a further boost when the visitors were reduced to 14 men when Adriaan Strauss was sin-binned with 14 minutes remaining for taking out Kearney in the air.
The Irish tails were in the air and forced a turnover close to the visitors line which ended with them being awarded a penalty and unlike last year when Sexton missed a penalty against the All Blacks from the same distance this time he struck it cleanly to make it 19-10.
Things were to get immeasurably better for the hosts minutes later as Sexton broke through the middle - Conor Murray chipped the resulting ball over the South African defence and Bowe was on hand to go over for his 27th try for his country.
The metronomic Sexton converted from the touchline for 26-10 and the Fields of Athenry resonated round the stadium.
The Irish added another penalty through Ian Madigan and Pietersen went over right at the end for a consolation try but it was way too little too late.
- AAP