Trainer Mick Price's Victoria Derby drought has ended with Tarzino giving his rivals a staying lesson in the $1.5 million race.
A clear-cut favourite, Tarzino settled midfield before starting his run at the 800m and joining the leaders on the turn.
The colt, the subject of a seven-figure offer from Hong Kong interests in the lead-up to Saturday's race, took control at the 400m and the result was never in doubt from the 200m.
Etymology claimed second with West Australian three-year-old Kia Ora Koutou taking the minor placing.
Price's best previous Derby result was a second with Kempinsky in 2003 and he admitted he was a nervous spectator as Tarzino reached the lead.