VIKINGS 48, EAGLES 30
Matt Cassel passed for 382 yards and two touchdowns and ran for another score to lead the injury-depleted Vikings over Philadelphia, snapping the Eagles' five-game winning streak.
With Adrian Peterson and Toby Gerhart out, Matt Asiata rushed for the first three touchdowns of his career and Greg Jennings caught a career-high 11 passes for 163 yards for the Vikings (4-9-1). Asiata ran for 51 yards on 30 carries.
Nick Foles threw for 428 yards with three touchdowns and one interception and DeSean Jackson had 10 catches for 195 yards and a score for the Eagles (8-6). They started the day with a one-game lead over Dallas in the NFC East.
Playing for pride and probably coach Leslie Frazier's job, the Vikings produced quite the spoiler performance against the previously surging Eagles.
FALCONS 27, REDSKINS 26
Desmond Trufant deflected Kirk Cousins' pass on a potential winning 2-point conversion with 18 seconds remaining, and the Atlanta Falcons edged the Washington Redskins.
The Falcons (4-10) scored 20 points off seven Washington turnovers. The Redskins (3-11) tied a team record with five lost fumbles.
Cousins passed for 381 yards and three touchdowns, but had three turnovers in his first start of the season after coach Mike Shanahan decided to bench Robert Griffin III. Griffin watched from the sideline. Cousins' touchdown pass to Santana Moss gave Washington a chance to force overtime by kicking the extra point. Instead, Cousins' attempted go-ahead 2-point pass for Pierre Garcon was deflected by Trufant.
Steven Jackson ran for two touchdowns for Atlanta. Alfred Morris had 98 yards rushing, but lost two fumbles for Washington.
49ERS 33, BUCCANEERS 14
Vernon Davis caught a touchdown pass for the fifth straight game and Michael Crabtree scored his first TD since returning from injury to help the San Francisco 49ers beat the Tampa Bay Buccaneers.
The victory was the fourth straight for Colin Kaepernick and the 49ers (10-4), who pulled away for good with a 10-minute, fourth-quarter drive that produced a field goal. Kendall Hunter put it well out of reach, scooping up a fumble on the ensuing kickoff and diving 2 yards into the end zone for a touchdown.
Tampa Bay got within 20-14 on Mike Glennon's TD pass to Tim Wright on the first play of the fourth quarter. The Bucs (4-10) didn't get the ball back until after Kaepernick used 17 plays to march the 49ers 77 yards into position for Phil Dawson to kick one of his four field goals, extending his franchise-record streak of consecutive successful attempts to 24.
Kaepernick completed 19 of 29 passes for 203 yards, two touchdowns and no interceptions. Frank Gore rushed for 86 yards to go over 1,000 in a season for the seventh time in his career.
Glennon was 18 of 34 for 179 yards, two touchdowns and one interception.
SEAHAWKS 23, GIANTS 0
Richard Sherman had two interceptions, Marshawn Lynch scored on a twisting, triple-effort 2-yard run, and Steven Hauschka kicked three field goals as Seattle manhandled the New York Giants for its sixth road win.
Russell Wilson toyed with New York's defense, running for 50 yards and throwing for 206 and a touchdown before sitting out the last few minutes. Wilson has 23 wins, the most for a quarterback in his first two seasons in the Super Bowl era.
The Seahawks (12-2) are closing in on the NFC West title and their best overall record; they went 13-3 in 2005 before losing to Pittsburgh in the Super Bowl.
Eli Manning was picked off a career-worst five times, with Byron Maxwell also getting two. The Giants (5-9) have their first losing record since 2004, and lost top receiver Victor Cruz to a concussion in the fourth quarter. Cruz is 2 yards short of his third straight 1,000-yard season.
BEASR 38, BROWNS 31
Jay Cutler shook off some early rustiness and threw three touchdown passes in his first start since Nov. 10, leading Chicago past Cleveland.
Cutler, who missed Chicago's previous four games with a sprained left ankle, threw a 4-yard TD pass to Earl Bennett with 5:41 left as Bears (8-6) rallied in the second half and stayed in contention for an NFC playoff spot. Cutler finished 22 of 31 for 265 yards and validated coach Marc Trestman's decision to stick with him over backup Josh McCown, who had played well while filling in for Chicago's starter.
Michael Bush's 40-yard TD run with 2:17 left sealed it for the Bears, who completed a four-game sweep of the AFC North and won their first road game since Nov. 4, when McCown led them to a win over Green Bay.
Tashuan Gipson returned an interception 44 yards for a TD and T.J. Ward had a 51-yard TD fumble return for the Browns (4-10). Jason Campbell finished 23 of 39 for 273 yards and one touchdown, a 43-yarder to Josh Gordon.
COLTS 25, TEXANS 3
Andrew Luck threw two touchdown passes, and Robert Mathis broke Indianapolis' single-season and career sacks records by forcing a second-half safety to lead the Colts past Houston.
Luck finished 19 of 32 for 180 yards with one interception and needed only two quarters to put up 20 points, four short of Indy's combined first-half point total from the previous six games. But the Colts (9-5) did it against a team that has lost 12 straight overall and is 0-12 all-time in Indy.
Mathis, the NFL sacks leader, now has 16 this season and 108 in his career, breaking the franchise records held by longtime teammate and close friend Dwight Freeney.
Case Keenum was 18 of 34 for 168 yards for Houston (2-12), and also was stripped of the ball by Mathis in the end zone, which led to the safety.
BILLS 27, JAGUARS 20
EJ Manuel threw two touchdown passes and ran for another score, leading the Buffalo Bills to a victory against the banged-up Jacksonville Jaguars.
Manuel bounced back from the worst game of his rookie season a four-interception performance at Tampa Bay last week and left his college state with his first win in five road starts.
The former Florida State star didn't do anything spectacular, just dinking and dunking the Jaguars for 193 yards. He also ran for 37 yards, including an 8-yard touchdown in the second quarter. Manuel completed 17 of 24 passes.
The Bills (5-9) scored 10 points in the final 2:14 of the first half, taking a 20-10 lead into the locker room. The Jaguars (4-10) rallied to tie it in the fourth, evening the score on Chad Henne's 13-yard TD pass to Marcedes Lewis.
Manuel answered, though, capping an 89-yard drive with a 1-yard TD pass to Frank Summers. With it, Manuel set the franchise's rookie record for touchdown passes with 11.
