There was only one winner from the hit.
The Steeler burrowed his head and rocked Moore in the helmet. It was an illegal collision and officials flagged Dupree for a 15-yard penalty.
His victim went straight down and took a while to get back up.
TJ Yates came on the field to replace the 32-year-old, but only for one play. Remarkably, Miami ruled out any serious concussion for its playmaker and Moore returned to finish the game.
The internet wasn't kind to Moore. No concern, no sympathy, no well wishes, just gags.
To be fair, some of the quips the Twittersphere came up with were pretty funny, even if they did come at the expense of someone's wellbeing.
But given Moore was cleared of any serious problems, we think you're allowed to have a bit of a chuckle at these.
Moore's almost immediate return didn't help his side though, as the Steelers crushed the Dolphins in the first round of the NFL playoffs, putting them two wins away from a Super Bowl appearance.
The Steelers took the early advantage and went into half-time up 20-6, with Moore suffering further ignominy after his initial hammering.
James Harrison sacked Moore, with the Dolphins deep in Pittsburgh territory late in the first half, to keep the Steelers comfortably in front.
The 38-year-old Harrison raced in on an unblocked Moore and jarred the ball loose.
Pittsburgh defensive end Stephon Tuitt recovered at Steelers 13. The turnover prevented the Dolphins from getting back into a game in which they were dominated for much of the opening 30 minutes.
Moore threw an interception and fumbled twice, but managed to set a franchise record for consecutive playoff completions with 14.
But that wasn't enough for the Dolphins, as the Steelers romped to victory.
