He helped carry Houston’s offense on a day when running back Dameon Pierce sat out with an ankle injury and the Texans managed just 53 yards rushing.
Noah Brown had six catches for 153 yards and a touchdown and Dalton Schultz added 10 catches for 130 yards and a touchdown for the Texans.
Mayfield threw for 265 yards and two touchdowns and the Buccaneers (3-5) dropped their fourth straight game.
Stroud led the Texans to touchdowns on their first three possessions of the second half to put them on top 30-23.
The Bucs tied it on a 1-yard run by Rachaad White before running back Dare Ogunbowale nailed a tiebreaking 29-yard field goal to put Houston on top 33-30 with about nine minutes to go. He handled the kickoff duties in the second half with kicker Kaʻimi Fairbairn out with a quadriceps injury. But Houston went for 2 on each of their three second-half touchdowns, before Ogunbowale made the big field goal.
He’s the first non-kicker or punter to make a field goal since Wes Welker did it on Oct. 10, 2004, for the Dolphins against New England.
Tampa Bay extended its lead to 20-10 on a 49-yard field goal by Chase McLaughlin early in the third quarter.
Brown took a short pass from Stroud and dashed 75 yards for a touchdown on the first play of the next drive to cut the lead. The Texans attempted a 2-point conversion with Fairbairn out. But Stroud was intercepted by Joe Tryon-Shoyinka leave the Bucs up 20-16.
McLaughlin added a 55-yard field goal to push it to 23-16 with 9½ minutes left in the third.
Schultz caught a 26-yard pass on third-and-11 to extend Houston’s next possession. Stroud then hit Dell in the corner of the end zone for a 29-yard TD that cut the lead to 23-22. The 2-point conversion failed when Stroud’s throw to Dell fell short.
Schultz grabbed a 9-yard pass for a touchdown early in the fourth quarter and Stroud ran for the 2-point conversion to put the Texans up 30-23 before White’s fourth-quarter score. A 53-yard reception by Mike Evans set up that score.
The Texans took a 7-3 lead when Stroud connected with Nico Collins on a 14-yard score with about nine minutes left in the first quarter.
Mayfield connected with Otton on a 3-yard TD pass to put Tampa Bay on top 10-7.
Mayfield threw a 9-yard pass to White on third down to get the Buccaneers to the 1. White waltzed into the end zone on the next play to push the lead to 17-7 with about nine minutes until halftime.
The Texans cut the lead to 17-10 on a 50-yard field goal by Fairbairn with five minutes left in the second quarter.
Schultz fumbled after a reception on Houston’s first drive, and it was recovered Antoine Winfield Jr. on the Houston 42. The Buccaneers took a 3-0 lead on a 35-yard field goal by McLaughlin.
Elsewhere in the NFL
Titans: 16 Steelers: 20
Dolphins: 14 Chiefs: 21
Vikings: 31 Falcons: 28
Seahawks: 3 Ravens: 37
Cardinals: 0 Browns: 27
Rams: 3 Packers: 20
Commanders: 20 Patriots: 17
Bears: 17 Saints: 24
Sunday Night Football: (2.20pm Mon NZT)
Bills @ Bengals
Monday Night Football: (2.15pm Tue NZT)
Chargers @ Jets
- with AP
