Colin Kaepernick's first start of the season came against a team featuring a Donald Trump-supporting head coach in a Rust Belt city that looked at the kneeling quarterback as sitting prey - literally.
Buffalo's tailgate scene on Sunday before the Bills' matchup against the 49ers was a ghastly one, filled with both disdain and fury for the quarterback who has been protesting the national anthem.
One salesman offered shirts featuring Kaepernick on a "Wanted" poster - with a target trained upon him.