Brady, a three-time Super Bowl MVP, and the Patriots (14-2) enjoy a first-round bye, along with the Kansas City Chiefs (12-4), who are led by quarterback and former first overall draft pick Alex Smith.
Rodgers, a Super Bowl MVP, led the Green Bay Packers (10-6) on a rousing charge into the post-season, finishing with six straight victories, while two-time Super Bowl winner Roethlisberger steered the Pittsburgh Steelers through an 11-5 campaign.
The Green Bay quarterback predicted the Packers could sweep the rest of their games, after struggling to a 4-6 start.
"That's what you have to do sometimes as a leader," Rodgers said, after Sunday's victory over the Detroit Lions to clinch the NFC North title.
"Exude confidence, even when it seems to the outside world confidence shouldn't exist."
Bucking the trend favouring experience at quarterback were the young Dallas Cowboys (13-3), who were led by rookie quarterback Dak Prescott and first-year running back Ezekiel Elliott, the NFL rushing leader.
Atlanta (11-5) are the NFC second seeds and will take the week off, along with Dallas.
The Wild Card round opens on Sunday (NZ), with the Oakland Raiders (12-4), devastated by the loss of starting quarterback Derek Carr to injury, taking on the Houston Texans (9-7), who are also playing a back-up signal caller.
The defence-minded Seahawks (10-5-1), who have been to two of the last three Super Bowls, host the Lions (9-7) and their strong-armed quarterback Matthew Stafford.
On Sunday, Roethlisberger and the Steelers host the Miami Dolphins (10-6), followed by a frigid meeting at Lambeau Field between the Giants (11-5) and the Packers (10-6).