Having toppled the Canterbury Tactix 50-45 in Porirua on Monday night, the Pulse were looking to record back-to-back wins for the first time in ANZ Championship history.
The Mystics on the other hand, were keen to bounce back from their first loss of the season after the Adelaide Thunderbirds defeated them 50-48 in Auckland last week.
The Pulse have have had issues with their mid-court during the first four weeks of the competition and coach Robyn Broughton again shook up her combinations for tonight's game.
While Joline Henry has been a constant at wing defence, wing attack has been a problem position and Camilla Lees appears to be the best player in that spot but she is also the team's premier centre.
Lees, Katarina Cooper and Ngarama Milner-Olsen have all spent time in the WA bib during the past three games and it was Milner-Olsen who was given the start tonight.
Milner-Olsen, who is shorter and quicker than the other two candidates, was tightly marked by Mystics wing defence Jade Clarke as the two engaged in a closely-fought battle in the first half.
The Mystics had the better of the opening two quarters, but a couple of late Caitlin Thwaites goals brought the Pulse within two as the teams went to the break.
In the third quarter the Pulse found another gear as they forced turnovers from the visitors and held the lead during the middle stages of the quarter before the Mystics restored their parity to lead by two heading in to the fourth.
The final 15 minutes of play was dominated by the Mystics who used their experience and calm under pressure to record their fourth win of the season from five games.
The game featured two of the most penalised players in the transtasman league, with Mystics goal defence Kayla Cullen (65) and Pulse defender Te Huinga Reo Selby-Rickit (62) having had the whistle blown against them numerous times during the first four games of the season.
Cullen was substituted with about four minutes to go in the second quarter having accumulated nine penalties in her typically robust fashion and was replaced by former Tactix defender Charlotte Kight, although Cullen returned for the fourth and final stanza.
Pulse shooter Caitlin Thwaites came in to the game having connected on the fourth-most goals in the competition having drained 117 goals at 87 per cent and the Australian imported was again impressive as she scored 33 goals from 37 attempts.
Northern Mystics 51 Central Pulse 47 1Q: 14-10, HT: 27-25 3Q: 38-36
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