The pole earned him one point and cut Palou's deficit to nine points when the green flag flew, but mayhem ensued before the very first turn on the permanent road course. Palou and Dixon hurtled toward the first turn and Felix Rosenqvist — the driver Palou replaced this year at Ganassi — appeared to clip Dixon.
It caused Dixon to lock his brakes as he and Palou rode side-by-side. Neither Ganassi car was going to make the turn and both followed Rosenqvist through a runoff to avoid crashing.
It took 10 laps under caution for IndyCar to figure out how to reorder the field, and Palou and Dixon were dropped to 17th and 18th for the restart on Lap 11 — the first lap under green. In all the ducking and weaving to avoid a multi-crash accident, O'Ward had cycled from seventh on the start to the lead before he even made it through the first turn, and yet Palou felt the race was still in his control.
As IndyCar took 10 laps to line the cars back up, Palou realized he'd likely have enough fuel to make the 110 laps on only two pit stops.
"I think when they were taking a long time to penalize us, I was counting laps and I was like 'OK, this is a good thing. I know we can make the fuel mileage to make it in two only stops,'" Palou said. "Even if we were on the same strategy as everybody, maybe we were not able to win, but we were able to be in the top five, top six. You never know."
Although O'Ward led 28 laps, he couldn't put a complete race together and the Ganassi drivers slowly picked their way back into contention. Palou had returned to the lead and was out front for a pair of restarts in the final 20 laps, holding off Alexander Rossi both times to preserve the victory.
The 24-year-old moved back atop the standings and takes a 25-point lead over O'Ward into next week's road course race at Laguna Seca in California. The season then concludes Sept. 26 on the streets of Long Beach, marking three tracks where Palou has never raced to close the season and his first championship.
"Laguna Seca is going to be good for us. We tested there. I feel strong there," Palou said. "Long Beach, that's going to be interesting and exciting, but nothing I can do about it. Never been there, all my competitors been there and won races there, so it's a bit scary."
Rossi finished a season-best second for his first podium of the season and was followed by Dixon, who despite finishing third lost ground in his bid for his seventh IndyCar title. The reigning champion went from 43 points down to O'Ward to 49 points behind Palou.
"It's definitely been a trying season for us, but ultimately if it comes down to we need to help Alex, that's fine, too," Dixon said. "I think for us it's about keeping the championship at home and at the team. Unless you're out, you're not out. It's all possible."
Jack Harvey finished fourth, and two-time series champion Josef Newgarden rallied from his 18th-place starting position to a fifth-place finish. He's fourth in the standings, 34 points behind Palou.