Lee sits three shots off the pace set by Dustin Johnson, who has completed his second round, and rank outsider Andrew Landry, who posted the lowest opening round in Oakmont US Open history.
Johnson is out for redemption after letting the U.S. Open slip away last year, when he was a 12-foot eagle putt away from winning and three-putted to finish one behind Jordan Spieth.
Johnson has recorded 11 top ten major finishes without breaking through for a first major title - a theme which is prominent throughout the leaderboard. Englishman Lee Westwood (11 top five major finishes) sits in third at three-under, while Sergio Garcia (10 top five major results) is a further shot behind.
While Lee will be focusing his attention on those names atop of the leaderboard, fellow Kiwi Tim Wilkinson will be nervously monitoring the middle of the pack.
In his first career major tournament, Wilkinson shot a five-over par 75 in his second round to sit at six-over, one shot outside the projected cut line.
However, with the majority of the field yet to complete their second round, it is expected that the cut line will rise and Wilkinson should get to play the weekend.
Whether he will be joined by golf's biggest stars is yet to be decided, with Jason Day and Rory McIlroy in danger of missing the cut.
Day is currently right on the cut line at five-over with three holes to play in his second round, while McIlroy carded a horror first round 77 to require a bounce-back second round to make the weekend. He is joined at seven-over par by Phil Mickelson, while Rickie Fowler and Justin Rose (six over), Henrik Stenson (nine over) and Hideki Matsuyama (12 over) are other highly fancied names struggling to fire.
The big weekend for New Zealand golfers also includes Lydia Ko, who is in a share of 13th through two rounds of the Meijer LPGA Classic.
In her first tournament since her second place finish at the Women's PGA Championship, Ko has carded rounds of 67 and 68 to sit at seven-under, three shots off the lead held by American Lexi Thompson.
Ko has finished in the top 25 in her last 18 LPGA Tour events, dating back to August 2015.