"I am not saying Papy Djilobodji is ready because he did not have chances to play and his is a different situation, but Zouma and Cahill are both ready and if John doesn't play, I go with them."
A victory in north London would strengthen Mourinho's belief his side have turned the corner after an abysmal start to the campaign that has left them in 15th position.
Their hopes of gaining revenge for the 5-3 defeat in the corresponding fixture last season will be enhanced if they can prevent Kane from extending a scoring streak that has brought the Tottenham striker nine goals in his last six club games.
Elsewhere in London, Arsene Wenger remains confident Arsenal can shake off their inconsistent form and mount a serious challenge for the Premier League title.
Wenger's side will attempt to bounce back from last weekend's surprise loss at West Bromwich Albion when they travel to Norwich City tonight, five days after keeping alive their hopes of reaching the Champions League knockout stages with victory over Dinamo Zagreb.
With their European campaign on the back-burner for two weeks, fourth-placed Arsenal can focus on catching Leicester City, the unexpected leaders who played Manchester United overnight.
Wenger believes that, with no one team dominating the title race, his side are still well placed in their bid to be crowned English champions for the first time since 2004.
"I don't even look at the league any more because it is very, very tight," Wenger said.
"Last week, we had a bad result against West Brom and so did Manchester City [against Liverpool], so it compacted the whole table.
"I believe it is a big opportunity for us but many teams can tell you that. We are in a position where you want to be after 13 games but there are 25 to go.
"If there are five or six to go and we are in the race, of course we are contenders. I think we have a chance but it is very early."
Arsenal's frustration at losing to West Brom was compounded by the fact they took the lead through Olivier Giroud. But Wenger insists this was not an indication his side remain vulnerable.
"You want to eradicate games like that. For us, it was a bad result," he said.
Arsenal midfielder Francis Coquelin will again be missing after being ruled out for three months with knee ligament damage, while Mikel Arteta and Theo Walcott are also sidelined.
Aaron Ramsey is in line to make his first start since suffering a hamstring problem in late October and Mathieu Flamini is expected to make only his second Premier League start of the season.
Alex Neil's Norwich side suffered a narrow 1-0 defeat at Chelsea last time out that left them in 16th place, three points above the relegation places.
-AAP
