He will still, of course, be surrounded by some very good players, but if he is to succeed in Russia where he fell short in Germany, South Africa and Brazil, he will have to elevate his game and those of his Argentina teammates without the sort of long, carefully nurtured support cast Barcelona's side of locally sourced talents came to provide for his outrageous ability.
It was no surprise Spain's international dominance between 2008 and 2012, during which they won the World Cup and two European Championships, coincided with Barcelona's own monopoly of the club game, since the same group of players provided the foundations for both sides.
There is seldom a substitute for real synergy in a team, but that is what Messi will be asked to trump as he bids to put Argentina on top of the pile for the first time since his compatriot and the player with whom he is most likened, Diego Maradona, managed to transform a good Argentina team into a great one at Mexico '86.
Spain are Argentina's opponents in a friendly in Madrid tomorrow and watching Jorge Sampaoli's side minus a "muscle fatigued" Messi mostly labour before a late flourish to win 2-0 against a very modest Italy in Manchester on Friday only reaffirmed the correlation between the Barcelona maestro and the hopes of the Albiceleste this summer.
In fairness, Sampaoli is making no attempt to downplay that reality. Even in a team with such attacking riches as Sergio Aguero, Gonzalo Higuain and Angel Di Maria - Juventus' Paulo Dybala and Inter's Mauro Icardi are, incredibly, not certain to make the cut - Sampaoli was talking about Messi "carrying this team on his shoulders".
The Argentina coach knows there are better, more complete sides than his in Russia, from pre-tournament favourites Germany and Brazil to France, Spain and even Belgium, but no one else has a player as singularly capable of winning a game so often as Messi.
If his talent can triumph, as it did in that final qualifying match against Ecuador when a hat-trick catapulted Argentina to victory and averted the ignominy of the country missing out on the tournament for the first time since 1970, it would rank as an achievement every bit as great as Maradona's personal tour de force 32 years ago.
Messi will turn 31 eight days after Argentina kick off their World Cup campaign against Iceland in Moscow. He will be well on the road to 36 by the time the subsequent tournament in Qatar comes around in November 2022.
It would be foolhardy to think that he would no longer be a force by then, but there is little doubt that this summer is likely to represent his last shot at world domination when his star is still firmly in the ascendancy.
Playing for Argentina may equate to life with Barca's recruits, so to speak, but one suspects those Friday games in Catalonia would not have been so one-sided had Messi swapped sides.