A-League club Perth will play English Premier League giants Chelsea in a friendly in mid-2018 at the new stadium in the West Australian capital.
The clash is expected to attract 65,000 fans, with many expected to come from Asia and interstate.
Glory CEO Peter Filopoulos said it was an enormous opportunity for sporting fans to see one of the best and biggest clubs in the world playing in their own backyard.
"This will not only help grow and foster football in Western Australia but will expose Perth Glory's brand to a new market and millions of viewers and fans around the globe.
"This will be Chelsea's only match in Australia during the A-League pre-season campaign and will play an important role in Perth Glory's preparations for the 2018/19 season" Filopoulos said.