Manchester City emphatically underlined their complete dominance of the Premier League as they beat Tottenham 4-1 to go 14 points clear at the top of the table.
Ilkay Gundogan put Pep Guardiola's side ahead with a 14th-minute header from a Leroy Sane corner and while Spurs had their moments, City ran away with it in the second half.
Kevin De Bruyne blasted in the second in the 70th minute and five minutes later City missed a penalty when Gabriel Jesus struck the post.
The third came 10 minutes from the end when Raheem Sterling tapped-in from close range after a typically devastating City counter-attack and the England forward added a fourth after a mistake from Eric Dier left him to cheekily round Lloris and slot home.
Christian Eriksen scored an injury-time consolation for Spurs with a fine solo effort.
Arsenal moved back into the Premier League's top four as Crystal Palace climbed out of the relegation places.
Mesut Ozil scored the only goal as Arsenal beat Newcastle to jump up to fourth place while Palace are now 14th following their 3-0 win at 10-man Leicester.
Arsenal ended a three-match winless run thanks to a brilliant strike from Ozil. It came in the 23rd minute when Alexis Sanchez's blocked shot fell to the German, who powered a left-footed volley past Rob Elliot.
The loss drops Newcastle, who are winless in nine, into the relegation zone. They replace Palace, whose first away win of the season vaulted them up the table.
Christian Benteke, Wilfried Zaha and Bakary Sako scored as the Eagles made it seven straight unbeaten. Leicester's Wilfred Ndidi was sent off in the second half after picking up his second yellow card.
Burnley were held to a 0-0 draw at Brighton but it was enough to lift the Clarets into fifth. Brighton's Glenn Murray missed a penalty and Burnley's James Tarkowski had a header cleared off the line.
Chelsea beat Southampton 1-0 for their eighth win in 10 league games. Marcos Alonso's long-distance free-kick was the difference as the Blues pulled level on points with second-place Manchester United, who play on Sunday.
Both teams had a man dismissed as Huddersfield won 4-1 at Watford. Aaron Mooy scored twice for the Terriers with Elias Kachunga and Laurent Depoitre each adding a goal.
Watford's Troy Deeney was shown a straight red card in the first half and Huddersfield's Jonathan Hogg was sent off for a second yellow in the 61st minute.
West Ham continued their revival under David Moyes, beating Stoke City 3-0 to heap more pressure on Mark Hughes.
Second-placed Manchester United play on Sunday at West Bromwich Albion