The number of fully vaccinated players to have received two doses now stands at 77 per cent, up from 68 per cent in October, while 92 per cent of players and club staff have received at least one dose of the vaccination. By contrast, in Italy's Serie A, the double vaccination rate is 98 per cent, while in Germany's Bundesliga it is 94 per cent.
Managers and players will get their chance to offer up their views at a meeting rescheduled for Friday and one source told Telegraph Sport: "They aren't happy."
Chelsea head coach Thomas Tuchel claimed the safety of his players had been overlooked by the Premier League's decision to reject a request to postpone their game against Wolverhampton Wanderers and the German must now prepare for three games in eight days, starting with Thursday's Carabao Cup tie against Brentford, with a heavily depleted squad.
The Football Association accepted a proposal to cancel replays in the third and fourth rounds of this season's FA Cup, but that is unlikely to fully appease the managers and players who believe the forthcoming schedule is too heavy.
A Premier League statement said: "It was confirmed at a Premier League club meeting today that, while recognising a number of clubs are experiencing Covid-19 outbreaks and challenges, it is the League's collective intention to continue the current fixture schedule where safely possible.
"The health and wellbeing of all concerned remains our priority and the League will continue to monitor and reflect public health guidance, always proceeding with caution."
The Premier League and its clubs have come under fire for late postponements over the past week and the statement added: "A range of issues were discussed at this afternoon's meeting, including the adaption of the Premier League COVID-19 postponement process in response to the impact of the Omicron variant."
Confirming the change to the FA Cup schedule, an FA statement said: "We can today confirm that replays have been removed in both the third and fourth rounds of the 2021-22 Emirates FA Cup.
"This exceptional decision was approved by the FA Board on Friday 17 December and has been taken in the wider interest of English football to alleviate the possibility of fixture congestion following several postponements in recent days and continued uncertainty ahead due to Covid-19.
"Ties in the third and fourth rounds of this season's competition will be played to a finish on the day, with extra-time and penalty shootouts if required. Replays will return up to and including the fourth round of the Emirates FA Cup from the 2022-23 season onwards."