Thankfully for Liverpool fans desperate to see their team back on top of English football for the first time in 30 years, the loss is far from terminal.
Four wins from their last 10 games will see the Reds become champions for the 19th time.
"There is no reason for panic," Liverpool defender Virgil van Dijk said.
"The [unbeaten] record, and the talk of the records, is all media. We just try to win every game ahead of us."
The performance will be a major concern, though, coming soon after a 1-0 loss to Atletico Madrid in the first leg of their Champions League round of 16 tie.
While Chelsea's forwards continue to struggle to score, at least the team can rely on their left back to find the back of the net.
Marcos Alonso made it three goals in two games since returning to the line-up after a two-month absence when he scored twice — including an 85th-minute equaliser — in a 2-2 draw at Bournemouth. The draw lifted fourth-placed Chelsea four points ahead of fifth-placed Manchester United, having played a game more.
Just when his team looked like being sucked into a relegation battle, former England manager Roy Hodgson has inspired Crystal Palace to back-to-back victories and most probably another season in the Premier League.
The 72-year-old Hodgson is poised for talks with the Palace board about a contract extension this week, and can go into them feeling fairly content about another solid season's work in the wake of a 1-0 win at Brighton.
Brighton are now only one point above the relegation zone.
Can the signing of a player from the second-tier League Championship be the catalyst for West Ham in their bid to secure safety in the Premier League?
Jarrod Bowen's lively performance in the 3-1 win over Southampton suggested so. Handed his first start since joining from Hull in the January transfer window, Bowen opened the scoring with a deft chip over goalkeeper Alex McCarthy and was a constant danger with his movement and pace in behind.
"That's the way it went in my dreams last night," Bowen said.
Newcastle and Burnley shared a 0-0 draw, with All White Chris Wood returning from injury with half an hour off the bench.
- AP