The latest casualties were Colombia centre back Davinson Sanchez, who injured his hamstring in their Champions League win on Wednesday, and England right back Kieran Trippier, who hobbled off injured midway through the first half against Palace.
Without really hitting their stride this season, Tottenham are in contention in the title race.
Five of their last six wins in the league have been by one goal, with their only league defeat since mid-September coming at home to leaders Manchester City.
"This type of game is crucial in the battle for the top four," said Spurs manager Mauricio Pochettino. "This is one of the toughest stadiums to play in. The three points are massive."
• Action on the field seemed very much an afterthought at King Power Stadium as Leicester honoured their late owner who was killed with four others in a helicopter crash two weeks ago.
The 0-0 draw with Burnley was the first game at the stadium since the tragic accident that saw Vichai Srivaddhanaprabha's helicopter crash after the previous home game.
Some injured Leicester players, including England defender Harry Maguire, led a march of fans from the city centre to the stadium ahead of the match. Fans, players and staff remembered Vichai before, during and after the game.
• On a rather lacklustre day in the Premier League where only 11 goals were scored in six matches, there were crucial and confidence-boosting second wins of the season for struggling Newcastle and Cardiff.
Newcastle climbed out of the relegation zone after beating Bournemouth 2-1 at home, with on-loan Venezuela striker Salomon Rondon setting Rafa Benitez's team on the way with two early goals.
After going 10 games without a victory at the start of the season, Newcastle have won two in a row.
Cardiff also won against Brighton 2-1, their winner coming in the 90th minute through Sol Bamba following an amazing goalmouth scramble in which the ball struck the goal frame twice before the centre back scored.
Brighton played from the 34th minute with 10 men after Dale Stephens' red card.
The other two games were 1-1 draws. Felipe Anderson's goal earned West Ham a point at Huddersfield, and Jose Holebas equalised with a deflected strike nine minutes from time to earn Watford a draw at Southampton, who were angered that a Charlie Austin goal was incorrectly disallowed for offside.
- AP